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J Biol Rhythms. 2017 Oct;32(5):423-432. doi: 10.1177/0748730417724250. Epub 2017 Sep 13.

Light Dominates Peripheral Circadian Oscillations in Drosophila melanogaster During Sensory Conflict.

Author information

1
Centre for Mathematics, Physics and Engineering in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK.
2
Ear Institute, University College London, London, UK.
3
Institute for Neuro- and Behavioral Biology, University of M√ľnster, Germany.
4
Gatsby Computational Neuroscience Unit, University College London, London, UK.

Abstract

In Drosophila, as in other animals, the circadian clock is a singular entity in name and concept only. In reality, clock functions emerge from multiple processes and anatomical substrates. One distinction has conventionally been made between a central clock (in the brain) and peripheral clocks (e.g., in the gut and the eyes). Both types of clock generate robust circadian oscillations, which do not require external input. Furthermore, the phases of these oscillations remain exquisitely sensitive to specific environmental cues, such as the daily changes of light and temperature. When these cues conflict with one another, the central clock displays complex forms of sensory integration; how peripheral clocks respond to conflicting input is unclear. We therefore explored the effects of light and temperature misalignments on peripheral clocks. We show that under conflict, peripheral clocks preferentially synchronize to the light stimulus. This photic dominance requires the presence of the circadian photoreceptor, Cryptochrome.

KEYWORDS:

Cryptochrome; Drosophila; circadian entrainment; circadian rhythms; luciferase; multisensory entrainment; period; peripheral clocks; sensory conflict; sensory integration

PMID:
28903626
DOI:
10.1177/0748730417724250
[Indexed for MEDLINE]

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