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Int J Mol Sci. 2017 Sep 13;18(9). pii: E1970. doi: 10.3390/ijms18091970.

Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.

Author information

1
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark. tholm@sund.ku.dk.
2
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark. ttn@sund.ku.dk.
3
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark. mgivskov@sund.ku.dk.
4
Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551, Singapore. mgivskov@sund.ku.dk.

Abstract

The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today's treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to "chemically" eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today's approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called "Quorum Sensing" together with intracellular signaling by bis-(3'-5')-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential.

KEYWORDS:

Pseudomonas aeruginosa; anti-virulence; biofilm life-cycle; cell signaling; cyclic-di-GMP; quorum sensing; small RNAs

PMID:
28902153
PMCID:
PMC5618619
DOI:
10.3390/ijms18091970
[Indexed for MEDLINE]
Free PMC Article

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