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Br J Nutr. 2017 Sep;118(5):368-374. doi: 10.1017/S0007114517002124.

The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial.

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1School of Biomedical Sciences,Australian Research Council (ARC) Industrial Transformation Training Centre for Functional Grains,Charles Sturt University,Wagga Wagga,NSW 2678,Australia.
2School of Medical and Applied Sciences,Central Queensland University,Rockhampton,QLD 4701,Australia.
4School of Medical Science,Griffith University,Gold Coast, QLD 4215,Australia.


The anti-thrombotic properties of anthocyanin (ACN) supplementation was evaluated in this randomised, double-blind, placebo (PBO) controlled, cross-over design, dietary intervention trial in sedentary population. In all, sixteen participants (three males and thirteen females) consumed ACN (320 mg/d) or PBO capsules for 28 d followed by a 2-week wash-out period. Biomarkers of thrombogenesis and platelet activation induced by ADP; platelet aggregation induced by ADP, collagen and arachidonic acid; biochemical, lipid, inflammatory and coagulation profile were evaluated before and after supplementation. ACN supplementation reduced monocyte-platelet aggregate formation by 39 %; inhibited platelet endothelial cell adhesion molecule-1 expression by 14 %; reduced platelet activation-dependant conformational change and degranulation by reducing procaspase activating compound-1 (PAC-1) (↓10 %) and P-selectin expression (↓14 %), respectively; and reduced ADP-induced whole blood platelet aggregation by 29 %. Arachidonic acid and collagen-induced platelet aggregation; biochemical, lipid, inflammatory and coagulation parameters did not change post-ACN supplementation. PBO treatment did not have an effect on the parameters tested. The findings suggest that dietary ACN supplementation has the potential to alleviate biomarkers of thrombogenesis, platelet hyperactivation and hyper-aggregation in sedentary population.


ACN anthocyanins; PAC-1; procaspase activating compound-1; PBO placebo; Anthocyanins; CVD; Platelet function; Thrombosis

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