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EXCLI J. 2017 Jun 28;16:959-972. doi: 10.17179/excli2017-475. eCollection 2017.

Physical activity and beta-amyloid pathology in Alzheimer's disease: A sound mind in a sound body.

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Department of Sports Science and Physical Education, Marand Branch, Islamic Azad University, Marand, Iran.
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Sports Science and Physical Education, Jolfa Branch, Islamic Azad University, Jolfa, Iran.
Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.


Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients' care, special attention has been paid to preventive interventions such as physical activity. Evidence shows that physical activity has protective effects on cognitive function and memory in AD patients. Several pathologic factors are involved in AD-associated cognitive impairment some of which are preventable by physical activity. Also, various experimental and clinical studies are in progress to prove exercise role in the beta-amyloid (Aβ) pathology as a most prevailing hypothesis explaining AD pathogenesis. This study aims to review the role of physical activity in Aβ-related pathophysiology in AD.


Alzheimer's disease; beta-amyloid; physical activity; prevention

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