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J Neurosci. 2017 Oct 11;37(41):10012-10021. doi: 10.1523/JNEUROSCI.0637-17.2017. Epub 2017 Sep 12.

Adaptation of Thalamic Neurons Provides Information about the Spatiotemporal Context of Stimulus History.

Author information

1
School of Biomedical Engineering, Science and Health System, Drexel University, Philadelphia, Pennsylvania 19104.
2
CINAC, University Hospital HM Puerta del Sur, CEU-San Pablo University, Móstoles, 28938 Madrid, Spain, moxon@ucdavis.edu gfoffani.hmcinac@hmhospitales.com.
3
Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain.
4
Neural Circuits and Cognition Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, and.
5
School of Biomedical Engineering, Science and Health System, Drexel University, Philadelphia, Pennsylvania 19104, moxon@ucdavis.edu gfoffani.hmcinac@hmhospitales.com.
6
Department of Biomedical Engineering, University of California, Davis, Davis, California 95616.

Abstract

Adaptation of neural responses due to the history of sensory input has been observed across all sensory modalities. However, the computational role of adaptation is not fully understood, especially when one considers neural coding problems in which adaptation increases the ambiguity of the neural responses to simple stimuli. To address this, we quantified the impact of adaptation on the information conveyed by thalamic neurons about paired whisker stimuli in male rat. At the single neuron level, although paired-pulse adaptation reduces the information about the present stimulus, the information per spike increases. Moreover, the adapted response can convey significant amounts of information about whether, when and where a previous stimulus occurred. At the population level, ambiguity of the adapted responses about the present stimulus can be compensated for by large numbers of neurons. Therefore, paired-pulse adaptation does not reduce the discriminability of simple stimuli. It provides information about the spatiotemporal context of stimulus history.SIGNIFICANCE STATEMENT The present work provides a computational framework that demonstrates how adaptation allows neurons to encode spatiotemporal dynamics of stimulus history.

KEYWORDS:

encoding; in vivo; sensory coding; somatosensory; vibrissae; whiskers

PMID:
28899918
PMCID:
PMC5637111
DOI:
10.1523/JNEUROSCI.0637-17.2017
[Indexed for MEDLINE]
Free PMC Article

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