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FASEB J. 2018 Jan;32(1):353-368. doi: 10.1096/fj.201700543R. Epub 2017 Sep 12.

Effects of aging and resistance training in rat tendon remodeling.

Author information

1
University of Brasília (UnB), Brasília, Distrito Federal, Brazil; marqueti@gmail.com.
2
University of Brasília (UnB), Brasília, Distrito Federal, Brazil.
3
Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
4
Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
5
Heminio Ometto University Center (UNIARARAS), Araras, São Paulo, Brazil.

Abstract

In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period. Aging in sedentary rats showed down-regulation in key genes that regulated ECM remodeling. Moreover, the OS group showed a calcification focus in the distal region of the CT, with reduced blood vessel volume density. In contrast, resistance training was effective in up-regulating connective tissue growth factor, VEGF, and decorin gene expression in old rats. Resistance training also increased proteoglycan content in young and old rats in special small leucine-rich proteoglycans and blood vessels and prevented calcification in OT rats. These findings confirm that resistance training is a potential mechanism in the prevention of aging-related loss in ECM and that it attenuates the detrimental effects of aging in tendons, such as ruptures and tendinopathies.-Marqueti, R. C., Durigan, J. L. Q., Oliveira, A. J. S., Mekaro, M. S., Guzzoni, V., Aro, A. A., Pimentel, E. R., Selistre-de-Araujo, H. S. Effects of aging and resistance training in rat tendon remodeling.

KEYWORDS:

calcaneal tendon; glycosaminoglycans; proteoglycans; strength training; turnover

PMID:
28899880
DOI:
10.1096/fj.201700543R
[Indexed for MEDLINE]

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