Format

Send to

Choose Destination
Autoimmun Rev. 2017 Nov;16(11):1160-1173. doi: 10.1016/j.autrev.2017.09.012. Epub 2017 Sep 9.

Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review.

Author information

1
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
2
Department of Internal Medicine IV, Medical University Innsbruck, Innsbruck, Austria.
3
Yonsei University College of Medicine, Seoul, Republic of Korea.
4
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: shinji@yuhs.ac.

Abstract

Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between "NETosis," which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.

KEYWORDS:

ANCA-associated vasculitis (AAV); Anti-neutrophil cytoplasmic antibodies (ANCA); Autoimmunity; Interleukin-8 (IL-8); Neutrophil extracellular traps (NETs); Neutrophils; Rheumatoid arthritis (RA); Systemic lupus erythematosus (SLE)

PMID:
28899799
DOI:
10.1016/j.autrev.2017.09.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center