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Phytomedicine. 2017 Oct 15;34:106-114. doi: 10.1016/j.phymed.2017.08.007. Epub 2017 Aug 9.

Tilianin pretreatment prevents myocardial ischemia-reperfusion injury via preservation of mitochondrial function in rat heart.

Author information

1
First Affiliated Hospital of the Medical College, Shihezi University, Xin Jiang 832008, China.
2
The Xinjiang Production and Construction Corps Hospital of Pharmacy, Urumqi 830002, China.
3
First Affiliated Hospital of the Medical College, Shihezi University, Xin Jiang 832008, China; Pharmacy of College, Shihezi University, Xinjiang 832002, China.
4
First Affiliated Hospital of the Medical College, Shihezi University, Xin Jiang 832008, China; Pharmacy of College, Shihezi University, Xinjiang 832002, China. Electronic address: cwjwxc@163.com.
5
College of Pharmaceutical Sciences and Innovative Drug Research Centre, Chongqing University, 55 South Daxuecheng Road, Chongqing 401331, China. Electronic address: ping.hu@cqu.edu.cn.

Abstract

BACKGROUND:

Tilianin has been demonstrated to exert protective effects on the heart against ischemia-reperfusion (I/R) injury, yet whether it is beneficial to the mitochondria during myocardial I/R is unclear.

METHODS:

In this study, we demonstrated that pretreatment with Tilianin dose-dependently raised the levels of ATP of the myocardium, and protected the microstructures and functions of mitochondria in rats. Furthermore, the cytoprotective effect of Tilianin has been confirmed in vivo and in the H9c2 cardiomyoblast cell line with enhancing activities of the mitochondria, controlling the levels of Ca2+ and reactive oxygen species (ROS), and inhibiting the expression of caspase-3 and AIF in cytoplasm.

CONCLUSIONS:

In conclusion, the study suggests that Tilianin may be of clinical value for the protective effects of cardiomyocytes and mitochondria by inhibiting myocardium energy metabolism and apoptosis during myocardial ischemia-reperfusion injury (MIRI).

KEYWORDS:

Apoptosis; MRI; Mechanisms; Mitochondria; Protective effect; Tilianin

PMID:
28899492
DOI:
10.1016/j.phymed.2017.08.007
[Indexed for MEDLINE]

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