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Dev Cell. 2017 Sep 11;42(5):436-438. doi: 10.1016/j.devcel.2017.08.018.

Arp2/3: Not Absolutely Required After All?

Author information

1
Institut für Medizinische Mikrobiologie, Virologie und Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Electronic address: s.linder@uke.de.

Abstract

The Arp2/3 complex nucleates branched actin networks and is thought to be essential for macrophage migration and phagocytosis. In this issue of Developmental Cell, Rotty et al. (2017) show that there is only a surprisingly specific requirement for Arp2/3 in integrin-dependent macrophage functions, including CR3 phagocytosis and haptotaxis on fibronectin.

PMID:
28898673
DOI:
10.1016/j.devcel.2017.08.018
[Indexed for MEDLINE]
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