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J Neurotrauma. 2018 Jan 15;35(2):398-401. doi: 10.1089/neu.2017.5172. Epub 2017 Nov 3.

Skeletal Muscle Atrophy and Degeneration in a Mouse Model of Traumatic Brain Injury.

Author information

1
1 Department of Orthopedic Surgery, University of California , San Diego, California.
2
2 Department of Anesthesiology, University of California , San Diego, California.

Abstract

Atrophy is thought to be a primary mode of muscle loss in neuromuscular injuries. The differential effects of central and peripheral injuries on atrophy and degeneration/regeneration in skeletal muscle tissue have not been well described. This study investigated skeletal muscle atrophy and degeneration/regeneration in an animal model of traumatic brain injury (TBI). Eight 8-month-old wild-type C57BL6 mice underwent either a sham craniotomy or TBI targeting the motor cortex. Atrophy (fiber area; FA) and degeneration/regeneration (centralized nuclei proportions; CN) of the soleus and tibialis anterior (TA) muscles were measured 2 months post-injury. Injured soleus FAs were smaller than sham soleus (pā€‰=ā€‰0.02) and injured TA (pā€‰<ā€‰0.001). Mean CNs were higher in the TBI-injured TA than in other muscles. Differential TBI-induced atrophy and degeneration/regeneration in lower limb muscles suggests that muscle responses to cortical injury involve more complex changes than those observed with simple disuse atrophy.

KEYWORDS:

atrophy; controlled cortical impact; degeneration; regeneration; skeletal muscle; traumatic brain injury

PMID:
28895461
PMCID:
PMC5784787
[Available on 2019-01-15]
DOI:
10.1089/neu.2017.5172

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