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Laryngoscope. 2018 Mar;128(3):E86-E90. doi: 10.1002/lary.26873. Epub 2017 Sep 12.

Chemosensory function before and after multimodal treatment in chronic rhinosinusitis patients.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Philipps University Marburg, Marburg, Germany.
2
Smell and Taste Clinic, Department of Otorhinolaryngology, Dresden Technical University, Dresden, Germany.
3
Center of Orthopedics and Traumatology, Philipps University Marburg, Marburg, Germany.
4
Department of Otorhinolaryngology-Head and Neck Surgery, Medical University Vienna, Vienna, Austria.
5
Department of Phoniatrics and Pediatric Audiology, Philipps University Marburg, Marburg, Germany.
6
Department of Otorhinolaryngology-Head and Neck Surgery, Chemnitz Hospital GmbH, Chemnitz, Germany.

Abstract

OBJECTIVES/HYPOTHESIS:

Olfactory dysfunction is common among the general population, with chronic rhinosinusitis (CRS) as one of the leading causes. Patients affected by CRS often report changes in taste sensations; however, quantitative measurements have not been performed to date. Therefore, the present study aimed to investigate gustatory and olfactory function in CRS patients prior to and after multimodal treatment.

STUDY DESIGN:

Prospective cohort study.

METHODS:

Twenty-one patients suffering from CRS with nasal polyps (14 male, seven female) with a mean age of 48 ± 15 years were included in the study. Chemosensory function was assessed prior to and approximately 190 days after multimodal treatment, which included endoscopic sinus surgery, oral antibiotics for 5 days, oral steroids for 12 days, and at least 6 weeks of topical nasal steroids. Olfactory function was tested with the Sniffin' Sticks test battery, whereas gustatory function was measured with taste strips. A clinically relevant change in olfactory function was defined as a change of ≥5 points in the threshold, discrimination, and identification scores.

RESULTS:

Compared to normative data, patients baseline gustatory and olfactory function was impaired. After multimodal treatment, improvements were seen in olfactory function for eight patients (42%), remained stable in 10 patients (53%), and deteriorated in one patient (5%). Taste function remained unchanged following sinus surgery.

CONCLUSIONS:

Patients suffering from CRS with polyps exhibit olfactory and taste dysfunctions. Multimodal treatment leads to an improvement in olfactory, but not gustatory functionality.

LEVEL OF EVIDENCE:

4. Laryngoscope, 128:E86-E90, 2018.

KEYWORDS:

Chronic rhinosinusitis; endoscopic sinus surgery; nasal polyps; olfaction; taste

PMID:
28895150
DOI:
10.1002/lary.26873
[Indexed for MEDLINE]

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