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Antiviral Res. 2017 Oct;146:164-173. doi: 10.1016/j.antiviral.2017.09.005. Epub 2017 Sep 8.

Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice.

Author information

1
Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
2
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
3
Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
4
Aldevron, Fargo, ND, USA.
5
SAB Biotherapeutics, Sioux Falls, SD, USA.
6
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.

Abstract

Zika virus (ZIKV) is rapidly spreading throughout the Americas and is associated with significant fetal complications, most notably microcephaly. Treatment with polyclonal antibodies for pregnant women at risk of ZIKV-related complications could be a safe alternative to vaccination. We found that large quantities of human polyclonal antibodies could be rapidly produced in transchromosomal bovines (TcB) and successfully used to protect mice from lethal infection. Additionally, antibody treatment eliminated ZIKV induced tissue damage in immunologically privileged sites such as the brain and testes and protected against testicular atrophy. These data indicate that rapid development and deployment of human polyclonal antibodies could be a viable countermeasure against ZIKV.

KEYWORDS:

Human polyclonal antibody; Testicular atrophy; Trans-chromosomal bovine; Zika

PMID:
28893603
DOI:
10.1016/j.antiviral.2017.09.005
[Indexed for MEDLINE]

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