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Neurosci Lett. 2017 Nov 1;660:79-85. doi: 10.1016/j.neulet.2017.09.010. Epub 2017 Sep 8.

Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis.

Author information

1
Laboratório de Farmacologia Comportamental, Dept. de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
2
Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.
3
Laboratório de Farmacognosia, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
4
Laboratório de Farmacologia Comportamental, Dept. de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: egavioli@hotmail.com.

Abstract

The genus Passiflora is popularly used to treat anxiety. Recent studies showed antidepressant-like effects of two varieties of P. edulis (edulis and flavicarpa) in mice. However, the mechanisms of antidepressant actions are still unknown. Here, the effects of P. edulis fo. edulis aqueous extract (AE, 100-300mg/kg, po), and ethyl acetate (AcOEt, 25-50mg/kg, po), butanol (BuOH, 25-50mg/kg, po) and residual aqueous (25-100mg/kg, po) fractions were investigated in the mouse forced swimming test. In addition, the involvement of monoamines in the P. edulis fractions-induced antidepressant actions was approached. HPLC analyses showed that AcOEt and BuOH, but not residual, fractions shared with AE the main peaks between 25 and 70min (UV 340nm), which are suggestive of flavonoids. Nortriptyline and fluoxetine reduced the immobility time and similar results were observed for AE, AcOEt and BuOH but not residual fractions. PCPA (inhibitor of 5-HT synthesis), AMPT (inhibitor of catecholamine synthesis) and sulpiride (selective D2 receptor antagonist), but not DSP-4 (noradrenergic neurotoxin), blocked the antidepressant actions of AcOEt and BuOH. In conclusion, AcOEt and BuOH fractions shared with AE similar phytochemical composition and antidepressant actions. Preserved 5-HT and dopamine transmissions were required for the antidepressant effects of P. edulis fractions.

KEYWORDS:

Antidepressants; Dopamine; Forced swimming test; Mouse; Passiflora edulis; Serotonin

PMID:
28893593
DOI:
10.1016/j.neulet.2017.09.010
[Indexed for MEDLINE]

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