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Endocr J. 2017 Dec 28;64(12):1181-1190. doi: 10.1507/endocrj.EJ17-0274. Epub 2017 Sep 9.

The relationship between chronic kidney function and homeostasis model assessment of insulin resistance and beta cell function in Korean adults with or without type 2 diabetes mellitus.

Author information

1
Department of Emergency Medical Technology, Chungbuk Health and Science University, Cheongju-si 28150, South Korea.
2
Department of Radiological Science, Hanlyo University, Gwangyang-si, 57764, South Korea.
3
Department of Health Science Graduate School, Chosun University, Gwangju 61457, South Korea.
4
Department of Nursing Graduate School, Chosun University, Gwangju 61457, South Korea.
5
Department of Biomedical Laboratory Science, Wonkwang Health Science University, Iksan-si, 54538, South Korea.
6
Department of Biomedical Laboratory Science, Hanlyo University, Gwangyang-si 57764, South Korea.

Abstract

The present study was conducted to assess the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in Korean adults with or without type 2 diabetes mellitus (T2DM). This study included 5,188 adults aged 20 or older using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents national data in Korea. A covariance test adjusted for covariates was performed for HOMA-IR and HOMA-B in relation to CKD. The present study has several key findings. First, in T2DM, HOMA-IR (p = 0.035) was higher in the CKD group than in the non-CKD group after adjusting for the related variables but HOMA-B (p = 0.141) was not significant. Second, in non-T2DM, HOMA-IR (p = 0.163) and HOMA-B (p = 0.658) were not associated with CKD after adjusting for the related variables (except age). However, when further adjusted for age, HOMA-IR (p = 0.020) and HOMA-B (p = 0.006) were higher in the CKD group than in the non-CKD group. In conclusion, insulin resistance was positively associated CKD with in Korean adults with or without T2DM. Beta cell function was positively associated CKD with in Korean adults without T2DM but not in Korean adults with T2DM.

KEYWORDS:

CKD; HOMA-B; HOMA-IR; T2DM

PMID:
28890482
DOI:
10.1507/endocrj.EJ17-0274
[Indexed for MEDLINE]
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