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J Clin Neurosci. 2017 Nov;45:115-120. doi: 10.1016/j.jocn.2017.08.010. Epub 2017 Sep 7.

The association between scabies and myasthenia gravis: A nationwide population-based cohort study.

Author information

1
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; Department of Pathology and Graduate Institute of Pathology and Parasitology, The Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: hsurnai@gmail.com.
2
Department of Pediatrics and Infectious Disease, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan. Electronic address: mmhped.lin@gmail.com.
3
Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: doc30666@gmail.com.
4
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Nursing, College of Medical and Health Science, Asia University, Taichung, Taiwan.
5
Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan. Electronic address: chuang20110617@yahoo.com.tw.
6
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan. Electronic address: mento1218@gmail.com.

Abstract

Scabies is an infectious inflammatory pruritic skin disease. Cytokine-mediated inflammatory processes contribute to the pathologic mechanism in scabies. Myasthenia gravis (MG) is also an autoimmune disease that is mediated by cytokines. The study aimed to investigate the association between scabies and myasthenia gravis. We conducted a nationwide population-based cohort study utilized data from the National Health Insurance Research Database (NHIRD) of Taiwan. Patients with scabies (n=5429) and control subjects without scabies (n=20,176) were enrolled. We tracked the subjects in both groups for a 7-year period to identify new onset MG. Cox regression analysis was performed to calculate the hazard ratio (HR) for MG. A total of 25,605 patients were enrolled in the study, including 5429 patients in the scabies group and 20,176 in the control group. There were 40 (0.7%) patients from the scabies group and 84 (0.4%) subjects from the control group who were newly diagnosed with MG during the 7-year follow-up period. The scabies patients had a significantly increased risk of MG, with an adjusted HR of 1.27 (95% confidence interval [CI] 1.01-1.89). As such, prompt diagnosis and treatment of scabies may decrease the risk of subsequent MG.

KEYWORDS:

Myasthenia gravis; National Health Insurance Research Database; Scabies

PMID:
28890037
DOI:
10.1016/j.jocn.2017.08.010
[Indexed for MEDLINE]

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