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Int J Cardiovasc Imaging. 2018 Feb;34(2):251-262. doi: 10.1007/s10554-017-1233-9. Epub 2017 Sep 9.

Myocardial contractile patterns predict future cardiac events in sarcoidosis.

Author information

1
Division of Cardiology, State University of New York, Upstate Medical University Hospital, 90 Presidential Plaza, Syracuse, NY, 13202, USA.
2
Department of Cardiology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China.
3
Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
4
Department of Radiology, State University of New York, Upstate Medical University Hospital, Syracuse, USA.
5
Department of Internal Medicine, State University of New York, Upstate Medical University Hospital, 750 E. Adams St., Syracuse, NY, 13210, USA. miannuzzi@northwell.edu.
6
Division of Cardiology, State University of New York, Upstate Medical University Hospital, 90 Presidential Plaza, Syracuse, NY, 13202, USA. liuk@upstate.edu.

Abstract

The poor prognosis of cardiac sarcoidosis (CS) underscores the need for risk stratification. We evaluated 84 consecutive sarcoidosis patients who were referred for echocardiographic studies for cardiac symptoms or abnormal electrocardiograms. In 54 patients without previous diagnosis of CS or other known structural heart disease, 13 reached endpoints during (median) 24 months follow up. Significantly impaired peak systolic longitudinal strain in their original echocardiograms were identified in 13 of 17 left ventricular segments, clustering in the free wall, interventricular septum and apex. The regional (including 13 clustered segments) peak systolic longitudinal strain (RPSLS) were significantly impaired in patients with endpoints, compared with those without [(-11.4 ± 4.45) vs. (-18.7 ± 3.76) %, P < 0.00001]. Cox multivariate regression analysis revealed that RPSLS was independently associated with endpoints (HR 1.24; 95% CI 1.08-1.42, P = 0.002). Receiver operating characteristic curve suggested a cut-off RPSLS value of -15.0% (84.6% sensitivity and 86.8% specificity) to predict the occurrence of endpoints. Impaired RPSLS correlates with risk of adverse cardiac events in patients with extra-cardiac sarcoidosis.

KEYWORDS:

Cardiac sarcoidosis; Regional peak systolic longitudinal strain; Risk stratification

PMID:
28889326
DOI:
10.1007/s10554-017-1233-9
[Indexed for MEDLINE]

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