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Curr Opin Immunol. 2017 Oct;48:82-91. doi: 10.1016/j.coi.2017.08.007. Epub 2017 Sep 7.

Immune monitoring for precision medicine in allergy and asthma.

Author information

1
Departments of Pathology, Stanford, CA 94305, USA; Departments of the Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.
2
Departments of Medicine, Stanford, CA 94305, USA; Departments of Pediatrics, Stanford, CA 94305, USA; Departments of the Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.
3
Departments of Pathology, Stanford, CA 94305, USA; Departments of Microbiology & Immunology, Stanford, CA 94305, USA; Departments of the Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA; Departments of the Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA. Electronic address: sgalli@stanford.edu.

Abstract

'Precision Medicine' embodies the analyses of extensive data collected from patients and their environments to identify and apply patient-specific prophylactic strategies and medical treatments to improve clinical outcomes and healthcare cost-effectiveness. Many new methods have been developed for evaluating the activity of the human immune system. Such 'immune monitoring' approaches are now being used in studies of allergy and asthma in the hope of identifying better correlates of disease status, predictors of therapeutic outcomes, and potential side-effects of treatment. Together with analyses of family histories, genetic and other biometric data, and measurements of exposures to environmental and other risk factors for developing or exacerbating disease, immune monitoring approaches promise to enable 'Precision Medicine' for allergic diseases and asthma.

PMID:
28889067
PMCID:
PMC5743231
DOI:
10.1016/j.coi.2017.08.007
[Indexed for MEDLINE]
Free PMC Article

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