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Arch Med Res. 2017 May;48(4):386-392. doi: 10.1016/j.arcmed.2017.08.003. Epub 2017 Sep 6.

Associations Between TNFAIP3 Gene Polymorphisms and Rheumatoid Arthritis Risk: A Meta-analysis.

Author information

1
Department of Orthopaedics, Jianggan District people's Hospital of Hangzhou, Hangzhou, Zhejiang, China.
2
Department of Orthopaedics, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
3
Department of Orthopaedics, Xiaoshan District Hospital of traditional Chinese Medicine of Hangzhou, Hangzhou, Zhejiang, China.
4
Department of Orthopaedics, Jianggan District people's Hospital of Hangzhou, Hangzhou, Zhejiang, China. Electronic address: dawei_zhangcnm@163.com.

Abstract

BACKGROUND AND AIMS:

A host of studies investigated the associations between tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs2230926 and rs5029937 polymorphisms and rheumatoid arthritis (RA) susceptibility, but with conflicting findings. Therefore, we explored whether TNFAIP3 gene rs2230926 and rs5029937 polymorphisms are associated with RA by meta-analysis.

MATERIAL AND METHODS:

We performed out a comprehensive literature search of PubMed, Elsevier, Embase, and CNKI databases to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations.

RESULTS:

Literature search identified 10 case-control studies involving 18,014 cases and 20,112 controls in this meta-analysis. Our data supported an association between TNFAIP3 gene rs2230926 and rs5029937 polymorphisms and RA risk. Stratification analysis of ethnicity indicated that rs5029937 polymorphism increased the risk of RA among Caucasians, while rs2230926 polymorphism increased the risk of RA among Asians and Caucasians.

CONCLUSIONS:

In conclusion, this meta-analysis demonstrates that TNFAIP3 gene polymorphisms (rs2230926 and rs5029937) are associated with the increased risk of RA.

KEYWORDS:

Meta-analysis; Rheumatoid arthritis; Single nucleotide polymorphism; TNFAIP3

PMID:
28888761
DOI:
10.1016/j.arcmed.2017.08.003
[Indexed for MEDLINE]

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