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Clin Plast Surg. 2017 Oct;44(4):793-803. doi: 10.1016/j.cps.2017.05.010. Epub 2017 Jul 21.

Peripheral Neuropathy and Nerve Compression Syndromes in Burns.

Author information

1
Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
2
Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Burn Wound and Regenerative Medicine Laboratory, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: blevi@med.umich.edu.

Abstract

Peripheral neuropathy and nerve compression syndromes lead to substantial morbidity following burn injury. Patients present with pain, paresthesias, or weakness along a specific nerve distribution or experience generalized peripheral neuropathy. The symptoms manifest at various times from within one week of hospitalization to many months after wound closure. Peripheral neuropathy may be caused by vascular occlusion of vasa nervorum, inflammation, neurotoxin production leading to apoptosis, and direct destruction of nerves from the burn injury. This article discusses the natural history, diagnosis, current treatments, and future directions for potential interventions for peripheral neuropathy and nerve compression syndromes related to burn injury.

KEYWORDS:

Nerve compression syndromes; Peripheral nerves; Peripheral neuropathy

PMID:
28888304
PMCID:
PMC5674779
DOI:
10.1016/j.cps.2017.05.010
[Indexed for MEDLINE]
Free PMC Article

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