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Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:97-103. doi: 10.1016/j.msec.2017.07.026. Epub 2017 Jul 18.

Innovative micro-textured hydroxyapatite and poly(l-lactic)-acid polymer composite film as a flexible, corrosion resistant, biocompatible, and bioactive coating for Mg implants.

Author information

1
Department of Material Science and Engineering, Seoul National University, Seoul 151-742, South Korea.
2
Department of Material Science and Engineering, Seoul National University, Seoul 151-742, South Korea; Biomedical Implant Convergence Research Lab, Advanced Institutes of Convergence Technology, Suwon-si, Gyeonggi-do 443-270, South Korea.
3
Department of Oral and Maxillofacial Surgery, Korea University Medical Center, Guro Hospital, Seoul 08308, South Korea.
4
Department of Oral and Maxillofacial Surgery, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Kyonggi-do 18450, South Korea.
5
Department of Oral and Maxillofacial Surgery, Clinical Trial Center, Seoul National University Dental Hospital, Seoul 110-744, South Korea.
6
Department of Material Science and Engineering, Seoul National University, Seoul 151-742, South Korea; Biomedical Implant Convergence Research Lab, Advanced Institutes of Convergence Technology, Suwon-si, Gyeonggi-do 443-270, South Korea. Electronic address: msbb419@snu.ac.kr.

Abstract

The utility of a novel ceramic/polymer-composite coating with a micro-textured microstructure that would significantly enhance the functions of biodegradable Mg implants is demonstrated here. To accomplish this, bioactive hydroxyapatite (HA) micro-dots can be created by immersing a Mg implant with a micro-patterned photoresist surface in an aqueous solution containing calcium and phosphate ions. The HA micro-dots can then be surrounded by a flexible poly(l-lactic)-acid (PLLA) polymer using spin coating to form a HA/PLLA micro-textured coating layer. The HA/PLLA micro-textured coating layer showed an excellent corrosion resistance when it was immersed in a simulated body fluid (SBF) solution and good biocompatibility, which was assessed by in vitro cell tests. In addition, the HA/PLLA micro-textured coating layer had high deformation ability, where no apparent changes in the coating layer were observed even after a 5% elongation, which would be unobtainable using HA and PLLA coating layers; furthermore, this allowed the mechanically-strained Mg implant with the HA/PLLA micro-textured coating layer to preserve its excellent corrosion resistance and biocompatibility in vitro.

KEYWORDS:

Biocompatibility; Biodegradability; Hydroxyapatite (HA); Magnesium (Mg); Micro-textured coating; Poly(l-lactic)-acid (PLLA)

PMID:
28888023
DOI:
10.1016/j.msec.2017.07.026
[Indexed for MEDLINE]

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