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Clin Exp Ophthalmol. 2018 May;46(4):356-363. doi: 10.1111/ceo.13058. Epub 2017 Oct 10.

Meta-analysis of accuracy of intraocular lens power calculation formulas in short eyes.

Author information

1
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
2
Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China.
3
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Abstract

IMPORTANCE:

Intraocular lens (IOL) power selection is a critical factor affecting visual outcome after IOL implantation in short eyes. Many formulas have been developed to achieve a precise prediction of the IOL power. However, controversy regarding the accuracy remains.

BACKGROUND:

To investigate the accuracy of different IOL power calculation formulas in short eyes.

DESIGN:

Meta-analysis.

PARTICIPANTS:

Patients with the axial length of eyes less than 22 mm from previously reported studies.

METHODS:

A comprehensive search in Pubmed, EMBASE, Cochrane Data Base of Systematic Reviews and the Cochrane Central Register of Controlled Trials was conducted by October 2016. We assessed the methodological quality using a modified QUADAS-2 tool and performed analysis on weighted mean differences of mean absolute errors (MAE) among different formulas.

MAIN OUTCOMES MEASURES:

The between-group difference of MAE was evaluated with weighted mean difference and 95% confidence intervals.

RESULTS:

Ten observational studies, involving 1161 eyes, were enrolled to compare six formulas: Haigis, Holladay 2, Hoffer Q, Holladay 1, SRK/T and SRK II. Among them, the Holladay 2 introduced the smallest overall MAE (0.496D) without statistical significance. The difference of MAE is statistically significant between Haigis and Hoffer Q (mean difference = -0.07D, P = 0.003), Haigis and SRK/T (mean difference = -0.07D, P = 0.009), Haigis and SRK II (mean difference = -0.41D, P = 0.01). For publication bias and small-study effect, neither funnel plot nor egger's test detected statistical finding.

CONCLUSION AND RELEVANCE:

The overall evidence from the studies confirmed the superiority of Haigis over Hoffer Q, SRK/T and SRK II in prediction IOL power in short eyes.

KEYWORDS:

cataract; intraocular lens power; mean absolute error; short eyes

PMID:
28887901
DOI:
10.1111/ceo.13058

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