Format

Send to

Choose Destination
Hum Hered. 1987;37(4):241-9.

DNA polymorphism of human HLA-linked complement C4 allotypes, including C4 null alleles, in the Finnish population.

Author information

1
Finnish Red Cross Blood Transfusion Service, Tissue Typing Laboratory, Helsinki.

Abstract

Human HLA-linked complement C4 gene products, C4A and C4B, show extensive genetic polymorphism. In both loci, an allele without a gene product, C4 null, is also observed. We have performed a restriction enzyme analysis of genomic DNA samples from individuals having all common (frequency over 1%) C4 protein allotypes observed in the Finnish population. Only one allotype-specific RFLP marker was observed. With some enzymes a DNA polymorphism was observed, which was not detectable by C4 protein typing. Analysis of 10 different C4B null haplotypes and 4 C4A null haplotypes suggested that only one haplotype, HLA-B8 C4A0 B1, carried a C4A gene deletion. This was observed in all 4 unrelated individuals homozygous for this haplotype.

PMID:
2888726
DOI:
10.1159/000153711
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center