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Behav Brain Res. 2018 Jan 15;336:219-226. doi: 10.1016/j.bbr.2017.09.011. Epub 2017 Sep 6.

Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease.

Author information

1
Translational Medicine Center, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou 450007, People's Republic of China. Electronic address: cuiyuanbo18@126.com.
2
School of Life Sciences, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
3
Department of Laboratory, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou 450007, People's Republic of China.
4
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.
5
Translational Medicine Center, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou 450007, People's Republic of China.
6
Stuyvesant High School, 345 Chambers St, New York, NY 10282, USA.
7
Translational Medicine Center, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou 450007, People's Republic of China. Electronic address: caoweiyu@hotmail.com.
8
School of Life Sciences, Zhengzhou University, Zhengzhou 450001, People's Republic of China. Electronic address: guanfangxia@126.com.

Abstract

Accumulating evidence suggests that oxidative stress induced by beta-amyloid (Aβ) is implicated in the pathlogical progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T), the simplest compound of the sulfur-containing dithiolethiones, has been proved to be a strongly active antioxidant factor by regulation of the nuclear factor E2-related factor 2 (Nrf2). Previous study reported that D3T confers protection to AD cell model in vitro, however, the neuroprotective effect of D3T in the AD mammalian model is unknown. In the present study, we aimed to evaluate the therapeutic potential of D3T in the Tg2576 AD mouse model and investigate the mechanisms underlying its beneficial effects. We showed that intraperitoneal administration of D3T significantly alleviated cognitive deficits in AD mice and dramatically decreased insoluble Aβ level and oxidative stress. Further mechanistic studies revealed that D3T significantly promoted hippocampal neurogenesis, and up-regulated levels of silent information regulator 1 (Sirt1), Nrf2 and heme oxygenase-1 (HO-1). Moreover, the positive effect of D3T on behavioral performance of AD mice was markedly attenuated by inhibition of the Sirt1/Nrf2 pathway by the antagonist EX527. In summary, our studies on a mouse AD model indicate that D3T could serve as a potential therapeutic agent for this devastating disease.

KEYWORDS:

Alzheimer’s disease; Cognition; D3T; Hippocampal neurogenesis; Nrf2; Oxidative stress; Sirt1

PMID:
28887195
DOI:
10.1016/j.bbr.2017.09.011
[Indexed for MEDLINE]

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