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Cytotherapy. 2017 Nov;19(11):1339-1349. doi: 10.1016/j.jcyt.2017.07.014. Epub 2017 Sep 5.

Cell therapies for Chagas disease.

Author information

1
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Centro Nacional de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, Rio de Janeiro, Brazil.
2
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Centro Nacional de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, Rio de Janeiro, Brazil. Electronic address: acarlos@biof.ufrj.br.

Abstract

In this review of cell therapies in Chagas disease, we cover aspects related to the disease, its treatment and world demographics, before proceeding to describe the preclinical and clinical trials performed using cell therapies in the search for an alternative therapy for the most severe and lethal form of this disease, chronic chagasic cardiomyopathy.

KEYWORDS:

Chagas disease; bone marrow cells; cardiomyopathy; cell therapy; mesenchymal stromal cells

PMID:
28887011
DOI:
10.1016/j.jcyt.2017.07.014
[Indexed for MEDLINE]

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