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Cell Stem Cell. 2017 Sep 7;21(3):297-300. doi: 10.1016/j.stem.2017.08.016.

Synergistic Engineering: Organoids Meet Organs-on-a-Chip.

Author information

1
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Regenerative Medicine, Yokohama City University, Yokohama, Japan. Electronic address: takanori.takebe@cchmc.org.
2
Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
3
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, University Health Network, Toronto, ON, Canada. Electronic address: m.radisic@utoronto.ca.

Abstract

Organoid technology and organ-on-a-chip engineering have emerged as two distinct approaches for stem cell-derived 3D tissue preparation. Their strategic integration can address each approach's limitations and provide a path toward a superior, synergistic strategy of constructing tissues that will truly deliver on the promise of regenerative and precision medicine.

PMID:
28886364
DOI:
10.1016/j.stem.2017.08.016
[Indexed for MEDLINE]
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