Format

Send to

Choose Destination
J Cell Physiol. 2018 Apr;233(4):3274-3281. doi: 10.1002/jcp.26171. Epub 2017 Sep 28.

Overexpression of miR-216b: Prognostic and predictive value in acute myeloid leukemia.

Zhang TJ1,2, Wu DH3, Zhou JD1,2, Li XX1,2, Zhang W1,2, Guo H2,4, Ma JC2,4, Deng ZQ2,4, Lin J2,4, Qian J1,2.

Author information

1
Department of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
2
The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City, Zhenjiang, Jiangsu, People's Republic of China.
3
Department of Hematology, The Third People's Hospital of KunShan City, Suzhou, Jiangsu, People's Republic of China.
4
Laboratory Center, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

Abstract

Accumulating studies have shown that miR-216b acted as a tumor suppressor and was down-regulated in solid tumors. However, little studies revealed the role or clinical implication of miR-216b in blood cancers. Herein, we reported miR-216b expression and its clinical significance in patients with acute myeloid leukemia (AML). In the current study, we analyzed bone marrow (BM) miR-216b expression in 115 de novo AML patients examined by real-time quantitative PCR. Notably, BM miR-216b expression was significantly up-regulated in AML patients, and could serve as a potential biomarker distinguishing AML from controls. No significant correlations of BM miR-216 expression were found with sex, age, white blood cells, hemoglobin, platelets, BM blasts, French-American-British classifications, and karyotypes. Significantly, patients with high miR-216b expression tended to have a lower frequency of FLT3-ITD mutation and higher incidence of U2AF1 and IDH1/2 mutations. Moreover, complete remission (CR) rate and overall survival were negatively affected by BM miR-216b overexpression among cytogenetically normal AML (CN-AML). Cox regression analyses showed that high BM miR-216b expression may act as an independent risk factor in CN-AML patients. Among the follow-up patients, BM miR-216b level in CR phase was markedly lower than in diagnosis time, and was returned in relapse phase. Collectively, our findings indicated that miR-216b overexpression was a frequent event in de novo AML, and independently conferred a poor prognosis in CN-AML. Moreover, miR-216b expression was a valuable biomarker correlated with disease recurrence in AML.

KEYWORDS:

AML; expression; miR-216b; prognosis

PMID:
28884855
DOI:
10.1002/jcp.26171

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center