Format

Send to

Choose Destination
Am J Ind Med. 2017 Nov;60(11):968-975. doi: 10.1002/ajim.22769. Epub 2017 Sep 7.

Cancer of the esophagus and asbestos exposure.

Clin B1,2,3, Thaon I4,5, Boulanger M1,2,3, Brochard P6,7,8, Chamming's S9, Gislard A10, Lacourt A6,7,8, Luc A4,5, Ogier G11, Paris C4,5, Pairon JC9,12,13,14.

Author information

1
INSERM U1086 « ANTICIPE », Caen, France.
2
CHU Caen, Service de santé au travail et pathologie professionnelle, Caen, France.
3
Université de Caen Normandie, Caen, France.
4
EA7298 INGRES, Nancy, France.
5
CHRU Nancy, Nancy, France.
6
INSERM U1219, Bordeaux Population Health, EPICENE, Univ. Bordeaux, Bordeaux, France.
7
Univ. Bordeaux, ISPED, INSERM U1219, Bordeaux Population Health, Bordeaux, France.
8
CHU Bordeaux, Bordeaux, France.
9
Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Créteil, France.
10
CHU Rouen, Service des maladies professionnelles, Rouen, France.
11
ERSM Rhône-Alpes, Regional security insurance, Lyon, France.
12
Centre Hospitalier Intercommunal Créteil, DHU A-TVB, Service de pneumologie et pathologie professionnelle, Créteil, France.
13
Institut Santé-Travail Paris-Est, Université Paris-Est Créteil, Faculté de Médecine, Créteil, France.
14
INSERM U955, Equipe 4, Créteil, France.

Abstract

BACKGROUND:

Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program).

METHODS:

A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos.

RESULTS:

We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95%CI 1.12-1.75]).

CONCLUSIONS:

This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus.

KEYWORDS:

asbestos; cancer; esophagus; incidence; mortality; occupational exposure

PMID:
28884469
DOI:
10.1002/ajim.22769
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center