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Eur J Nutr. 2017 Sep 7. doi: 10.1007/s00394-017-1528-6. [Epub ahead of print]

Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review.

Li YJ1,2, Li YM3, Xiang DX4,5.

Author information

1
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
2
Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.
3
Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
4
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. xiangdaxiong@163.com.
5
Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China. xiangdaxiong@163.com.

Abstract

PURPOSE:

Nutritional supplements have been used for correction of deficiencies that may occur in patient with autism spectrum disorder (ASD) and to improve core symptoms. We aim to provide current best evidence about supplements for nutritional deficiencies and core symptoms in children with ASD and to evaluate the effectiveness and safety.

METHODS:

A systematic literature search of scientific databases was performed to retrieve relevant randomized controlled trials. Risk of bias was assessed for each study.

RESULTS:

18 randomized controlled trials of five supplements were included. B6/Mg was not helpful for improving ASD symptoms (seven RCTs). Two RCTs of methyl B12 reported some improvement in ASD severity but the effects on the correction of deficiencies were inconclusive. Two RCTs of vitamin D3 both reported increased levels of mean 25(OH)D in serum but inconsistent results in behavioral outcomes. Omega-3 fatty acid supplementation did not affect ASD behaviors but may correct deficiencies (six RCTs). One RCT of folinic acid reported positive results in improving ASD symptoms measured by various behavioral scales.

CONCLUSIONS:

Current evidence for the use of supplements for correcting nutritional deficiencies in children with ASD and to improve the symptoms is little. More studies are needed.

KEYWORDS:

Autism spectrum disorder; Core symptoms; Nutritional deficiency; Supplements

PMID:
28884333
DOI:
10.1007/s00394-017-1528-6
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