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Schizophr Res. 2018 May;195:591-593. doi: 10.1016/j.schres.2017.08.044. Epub 2017 Sep 5.

Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants.

Author information

1
Clinical Neuroscience Lab, Federal University of Sao Paulo, Sao Paulo, Brazil; Center for Neuromodulation Studies, Dep. of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil. Electronic address: july.flp@gmail.com.
2
Clinical Neuroscience Lab, Federal University of Sao Paulo, Sao Paulo, Brazil; Center for Neuromodulation Studies, Dep. of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
3
Clinical Neuroscience Lab, Federal University of Sao Paulo, Sao Paulo, Brazil.
4
Itallis Consciousness Technologies, Atlanta, GA, USA.
5
Epidemiology and Biostatistics Unity, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Brazil.
6
Center for Neuromodulation Studies, Dep. of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil; Reference Center for Alcohol, Tobacco and Other Drugs (CRATOD), São Paulo State Secretariat of Health, São Paulo, Brazil.

Abstract

BACKGROUND:

Cognitive impairments in schizophrenia are strongly correlated to functional outcome and recovery rates, with no pharmacological agent approved for its treatment. Neurofeedback has emerged as a non-pharmacological approach to enhance neuroplasticity, which consists in inducing voluntary control of brain responses through operant conditioning.

METHOD:

The effects of hemoencephalography neurofeedback (HEG-NFBK) in 4 brain sites (F7, Fp1, Fp2 and F8) was studied in 8 patients with schizophrenia (SCH, mean age 36.5±9.98) and 12 health controls (mean age 32.17±5.6). We analyzed groups' performance (10 sessions) and cognitive differences in 3 time points (baseline, after training and follow-up) with generalized estimated equations. For SCH we also evaluate the impact on psychopathology.

RESULTS:

We found a group∗time interaction for HEG-NFBK performance in the left hemisphere sites (F7 an Fp1) and a near-to-significant in the right frontotemporal region (F8), with no group differences and a significant time effect. Most of cognitive domains improved after intervention, including information processing speed, attention processing, working memory, executive functioning, verbal and visual learning. No group∗time interaction was found. Results suggest that both groups benefit from HEG-NFBK training regardless of cognitive differences at baseline. No significant time effects were found for Calgary and PANSS total scale and subscales (positive, negative neither general).

CONCLUSION:

To our knowledge, this is the first controlled trial showing effects of NFBK on cognitive performance improvement in schizophrenia. Further research investigating the effects of HEG-NFBK training in schizophrenia should be performed.

KEYWORDS:

Hemoencephalography neurofeedback; Neurofeedback; Non-invasive brain stimulation; Psychosis; Schizophrenia

PMID:
28882685
DOI:
10.1016/j.schres.2017.08.044
[Indexed for MEDLINE]

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