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Allergol Int. 2017 Oct;66(4):539-544. doi: 10.1016/j.alit.2017.08.004. Epub 2017 Sep 4.

Role of the microbiota in skin immunity and atopic dermatitis.

Author information

1
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
2
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address: yumi01@chiba-u.jp.
3
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. aureus in the pathogenesis of AD remains poorly understood. In addition to S. aureus, recent studies show a contribution of the skin microbiota to the regulation of immune responses in the skin as well as to the development of inflammatory skin disease. This review summarizes current knowledge about the role of the microbiota in skin immune responses and the role of S. aureus virulent factors in the pathogenesis of AD.

KEYWORDS:

Atopic dermatitis; Microbiota; Quorum sensing; Staphylococcus aureus; δ-toxin

PMID:
28882556
DOI:
10.1016/j.alit.2017.08.004
[Indexed for MEDLINE]
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