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Oncotarget. 2017 May 10;8(32):53829-53838. doi: 10.18632/oncotarget.17754. eCollection 2017 Aug 8.

Microbiota-gut-brain axis and the central nervous system.

Zhu X#1, Han Y#2, Du J#3, Liu R1, Jin K4, Yi W1.

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Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China.
Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
Department of Gastroenterology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, P.R. China.
Contributed equally


The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis. In this paper, we will review the latest advances of studies on the correlation between gut microorganisms and CNS functions & diseases.


central nervous system; disorders; gut microorganism; microbiota-gut-brain axis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing interests.

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