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Oncotarget. 2017 Mar 15;8(31):50941-50948. doi: 10.18632/oncotarget.16222. eCollection 2017 Aug 1.

The prognostic role of pretreatment epidermal growth factor receptor T790M mutation in advanced non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitors.

Author information

1
Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
2
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
3
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
4
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
5
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
#
Contributed equally

Abstract

PURPOSE:

The outcome of pretreatment epidermal growth factor receptor (EGFR) T790M mutation in EGFR mutant non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (TKIs) is controversial, this study aimed to evaluate the prognostic role of pretreatment T790M in advanced NSCLC patients treated with EGFR TKIs.

RESULTS:

A total of 7 eligible studies containing 179 cases and 281 controls were included in the meta-analysis. The pooled hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were 2.21 (95% CI 1.49-3.29, P<0.001) and 1.24 (95% CI 0.90-1.71, P=0.186), respectively. We also did subgroup analyses on OS and PFS according to patients from various districts.

METHODS:

Identified literatures from various databases were reviewed. A meta-analysis was performed to evaluate the prognostic role of pretreatment EGFR T790M in advanced EGFR mutant patients treated with EGFR TKIs.

CONCLUSIONS:

Pretreatment T790M may be a poor prognostic factor for PFS in advanced NSCLC patients treated with EGFR TKIs. However, no significant prognostic effect was found between pretreatment T790M mutation and OS. More studies are needed to demonstrate the prognostic role of pretreatment T790M mutation in advanced NSCLC patients.

KEYWORDS:

EGFR TKI; NSCLC; meta-analysis; pretreatment T790M; prognosis

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