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Mov Disord. 2017 Nov;32(11):1631-1636. doi: 10.1002/mds.27120. Epub 2017 Sep 7.

Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts.

Author information

1
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
2
Institute of Environmental Medicine, Unit of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.
3
Department of Psychology, University of Southern California, Los Angeles, California, USA.
4
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Abstract

BACKGROUND:

A neuroprotective effect of dietary antioxidants on Parkinson's disease (PD) risk has been suggested, but epidemiological evidence is limited.

OBJECTIVES:

To examine the associations between intake of dietary antioxidant vitamins and total antioxidant capacity and risk of PD.

METHODS:

We prospectively assessed the relationships of dietary antioxidant vitamins C and E, ß-carotene, and total antioxidant capacity with PD risk in two population-based cohorts (38,937 women and 45,837 men).

RESULTS:

During a mean 14.9-year follow-up period, 1,329 PD cases were identified. Dietary intake of ß-carotene was associated with a lower risk of PD (hazard ratio: 0.86; 95% confidence interval: 0.78-0.95; Ptrend  < 0.01 for women and hazard ratio: 0.91; 95% confidence interval: 0.84-0.99; Ptrend  = 0.05 for men). An inverse association between dietary vitamin E and PD risk was found in women (hazard ratio: 0.87; 95% confidence interval: 0.79-0.96; Ptrend  = 0.02). Dietary intake of vitamin C was inversely associated with PD risk in women at borderline significance (hazard ratio: 0.91; 95% confidence interval: 0.83-1.00; Ptrend  = 0.04). There was no association between dietary total antioxidant capacity and PD risk in either women (hazard ratio: 0.93; 95% confidence interval: 0.84-1.02; Ptrend  = 0.35) or men (hazard ratio: 1.00; 95% confidence interval: 0.93-1.07; Ptrend  = 0.97).

CONCLUSION:

Intake of dietary vitamin E and ß-carotene was associated with a lower risk of PD. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

KEYWORDS:

Parkinson's disease; antioxidants; diet; risk factors

PMID:
28881039
PMCID:
PMC5698752
DOI:
10.1002/mds.27120
[Indexed for MEDLINE]
Free PMC Article

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