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Org Lett. 2017 Sep 15;19(18):4972-4975. doi: 10.1021/acs.orglett.7b02464. Epub 2017 Sep 7.

Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides.

Author information

1
Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University , Shanghai 201210, China.
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
3
University of Chinese Academy of Sciences , Beijing 100049, China.

Abstract

A new class of N-phenyl-divinylsulfonamides which can be easily prepared have been successfully developed and utilized as efficient linkers in the field of disulfide bond modification. Functional divinylsulfonamides provide opportunities for the specific introduction of various functionalities, including affinity probes, fluorescent tags, and drugs, into peptides.

PMID:
28880566
DOI:
10.1021/acs.orglett.7b02464
[Indexed for MEDLINE]

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