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Toxicol Ind Health. 2017 Oct;33(10):775-791. doi: 10.1177/0748233717718974. Epub 2017 Sep 7.

Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods.

Author information

1
1 Bagcilar Training and Research Hospital, Pediatrics, Istanbul, Turkey.
2
2 Faculty of Pharmacy, Department of Toxicology, Gazi University, Ankara, Turkey.
3
3 Haydarpasa Numune Training and Research Hospital, Department of Pathology, Istanbul, Turkey.
4
4 Bagcilar Training and Research Hospital, Department of Biochemisty, Istanbul, Turkey.
5
5 Bagcilar Training and Research Hospital, Veterinarian, Istanbul, Turkey.
6
6 Bagcilar Training and Research Hospital, Department of Pathology, Istanbul, Turkey.
7
7 Department of Pediatric Endocrinology, Istanbul University Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.

Abstract

Homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) are ultraviolet filters. We aimed to investigate the effects of dermal exposure to HMS and OD-PABA during the prenatal, lactation, and early infancy periods on pubertal development and thyroid function in male and female rats. The thyroid glands, uteri, testes, prostate glands, and seminal vesicles were excised and weighed, the reproductive organs were analyzed histologically, and the serum hormone levels were measured. In the prenatal period, the thyroxine (T4) levels increased in the female rats in the exposed groups ( p < 0.05); the thyroid weights, reproductive organ weights, and gonadal hormone levels were not altered. In males, the testosterone levels decreased ( p < 0.05), but the thyroid weights, T4 levels, prostate, and testis weights were not changed. In the lactation period, the weights of the thyroid glands increased in the exposed female groups ( p < 0.05), but the T4, gonadal hormone levels, and reproductive organ weights were not changed. In the males, the thyroid gland weights, T4 levels, reproductive organ weights, and gonadal hormone levels were not changed. During infancy, the thyroid gland weights increased in the female rats in the exposed groups ( p < 0.05), but the T4 levels, gonadal hormone levels, and reproductive organ weights were not affected. In the male rats in the exposed groups, the T4 levels were increased ( p < 0.05), but the thyroid and reproductive organ weights, gonadal hormone levels were not affected. Organ histopathology was not affected in all groups. HMS and OD-PABA do not have endocrine disruptor effects on thyroid function and the pubertal development of female and male rats.

KEYWORDS:

Endocrine disruptors; HMS; OD-PABA; rat

PMID:
28879804
DOI:
10.1177/0748233717718974
[Indexed for MEDLINE]

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