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Tex Heart Inst J. 2017 Aug 1;44(4):269-273. doi: 10.14503/THIJ-16-5823. eCollection 2017 Aug.

Transcatheter Mitral Valve Replacement with the Edwards Sapien 3 Valve.


We describe the case of a 57-year-old man who had severe mitral valve stenosis and regurgitation without significant annular calcification. He was not a candidate for surgical valve replacement or repair because of his substantial comorbid conditions, overall frailty, and elevated surgical risk. He underwent successful transcatheter mitral valve replacement of his native mitral valve with compassionate, off-label use of an Edwards Sapien 3 valve. A search of the literature produced no other cases like ours, which represents a further evolution of the transcatheter valve implantation concept. Further studies are needed to help define accurate valve sizing, intraprocedural positioning, and long-term device stability, as well as to determine which patients might benefit from this commercially available valve. In the meantime, our findings could present a means of treating patients who have no other options.


Heart valve prosthesis implantation/instrumentation/methods; mitral valve insufficiency/diagnostic imaging; mitral valve stenosis; prosthesis design; risk factors; transcatheter mitral valve replacement/methods; treatment outcome

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