Format

Send to

Choose Destination
Sci Rep. 2017 Sep 6;7(1):10669. doi: 10.1038/s41598-017-10993-9.

Swapping of transmembrane domains in the epithelial calcium channel TRPV6.

Author information

1
Department of Biochemistry and Molecular Biophysics, Columbia University 650 West 168th Street, New York, NY, 10032, USA.
2
Department of Biochemistry and Molecular Biophysics, Columbia University 650 West 168th Street, New York, NY, 10032, USA. as4005@cumc.columbia.edu.

Abstract

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center