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Med Sci Monit. 2017 Sep 7;23:4312-4320.

Analysis of Antineutrophil Cytoplasm Antibody from 118 730 Patients in Tertiary Hospitals in Jiangxi Province, China.

Author information

1
Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
2
School of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
3
Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
4
Department of Clinical Laboratory, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China (mainland).
5
Department of Clinical Laboratory, Jiangxi Provincial Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).
6
Department of Clinical Laboratory, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
7
Department of Clinical Laboratory, The Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China (mainland).
8
Department of Clinical Laboratory, Yichun People's Hospital of Jiangxi Province, Yichun, Jiangxi, China (mainland).
9
Department of Clinical Laboratory, Ganzhou People's Hospital of Jiangxi Province, Ganzhou, Jiangxi, China (mainland).
10
Department of Clinical Laboratory, Pingxiang People's Hospital of Jiangxi Province, Pingxiang, Jiangxi, China (mainland).

Abstract

BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively. RESULTS Among 118 730 patients, a total of 5853 (4.93%) were positive for ANCA. In the positive cases, 3.98% were male and 6.33% were female, with significant differences (χ²=123.38, P<0.01). For ANCA, the department with the highest positive rate (15.06%) was the Department of Rheumatology, followed by 7.78% in the Department of Dermatology, 6.79% in the Department of Nephrology, and 5.72% in the Department of Traditional Chinese Medicine (TCM). Anti-PR3 and cANCA were highly specific in primary vasculitis (P<0.01). Anti-MPO and pANCA had high specificity for other autoimmune diseases (P<0.01). CONCLUSIONS ANCA has important guiding significance for vasculitis-related diseases. Therefore, it is important in the diagnosis and treatment of this disease and has value in clinical practice.

PMID:
28878204
PMCID:
PMC5600193
DOI:
10.12659/msm.905880
[Indexed for MEDLINE]
Free PMC Article

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