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Int J Mol Sci. 2017 Sep 6;18(9). pii: E1913. doi: 10.3390/ijms18091913.

Melatonin and Hippo Pathway: Is There Existing Cross-Talk?

Author information

1
Oncogenomic and Epigenetic Unit, Molecular Chemoprevention Group, Department of Research, Diagnosis and Innovative Technologies, Translational Research Area, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. federica.losardo@ifo.gov.it.
2
Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, ON L8S 4L8, Canada. muti@mcmaster.ca.
3
Oncogenomic and Epigenetic Unit, Molecular Chemoprevention Group, Department of Research, Diagnosis and Innovative Technologies, Translational Research Area, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. giovanni.blandino@ifo.gov.it.
4
Oncogenomic and Epigenetic Unit, Molecular Chemoprevention Group, Department of Research, Diagnosis and Innovative Technologies, Translational Research Area, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. sabrina.strano@ifo.gov.it.

Abstract

Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation of circadian rhythms and antioxidant properties to the induction and maintenance of tumor suppressor pathways. It binds to specific receptors as well as to some cytosolic proteins, leading to several cellular signaling cascades. Recently, the involvement of melatonin in cancer insurgence and progression has clearly been demonstrated. In this review, we will first describe the structure and functions of melatonin and its receptors, and then discuss both molecular and epidemiological evidence on melatonin anticancer effects. Finally, we will shed light on potential cross-talk between melatonin signaling and the Hippo signaling pathway, along with the possible implications for cancer therapy.

KEYWORDS:

GPCR signaling; Hippo pathway; cancer; melatonin; melatonin receptors

PMID:
28878191
PMCID:
PMC5618562
DOI:
10.3390/ijms18091913
[Indexed for MEDLINE]
Free PMC Article

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