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Aliment Pharmacol Ther. 2017 Nov;46(9):836-844. doi: 10.1111/apt.14290. Epub 2017 Sep 6.

Food elimination diets are effective for long-term treatment of adults with eosinophilic oesophagitis.

Author information

1
Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Abstract

BACKGROUND:

Limited data describe the long-term efficacy of dietary elimination in eosinophilic oesophagitis (EoE).

AIM:

To assess the long-term outcomes of food elimination diets for treatment of adults with EoE.

METHODS:

We conducted a retrospective cohort study at our centre analysing all EoE patients receiving a food elimination diet without concomitant steroids. Baseline data were abstracted using standardised collection forms. Follow-up data from a mean 24.9-month period were collected for patients with a histological response to a food elimination diet during and after food reintroduction. The main outcomes were symptomatic, endoscopic and histological responses.

RESULTS:

Of 52 patients, 18 received a 6-food food elimination diet, 32 received targeted diet, and two received a 6-food food elimination diet with targeted elimination. There were 21 (40%) patients with an initial histological response. Responders reported less dysphagia after treatment (95% baseline vs 11%; P = .001) and at the end of follow-up (95% baseline vs 33%; P = .008). Significant and durable endoscopic improvements were recorded at the same time points: Endoscopic reference score: 3.2 vs 0.7; P = .001; and 3.2 vs 1.7; P = .06. Histological findings improved after the most restrictive diet in responders (49.8 vs 4.1 eosinophils per high-power field; P = .001) and remained suppressed in the 10 initial responders maintaining compliance at the end of follow-up (5.2 eosinophils per high-power field).

CONCLUSIONS:

Among EoE patients responding to a food elimination diet and remaining adherent, maintenance dietary therapy produced durable long-term symptomatic, endoscopic and histological disease control. These long-term data confirm that a food elimination diet is an effective maintenance treatment option in select adults with EoE.

PMID:
28877359
PMCID:
PMC5659358
DOI:
10.1111/apt.14290
[Indexed for MEDLINE]
Free PMC Article

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