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Glycosphingolipids.

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Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017.Chapter 11.
2017.

Author information

1
Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
2
Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
3
Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
4
Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
5
Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
6
Professor of Mycology, ETH Zürich, Zürich, Switzerland
7
Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
8
Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
9
Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
10
Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
11
Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
12
Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

Excerpt

Glycosphingolipids (GSLs), a subclass of glycolipids found in the cell membranes of organisms from bacteria to humans, are the major glycolipids of animals. The emphasis of this chapter is on vertebrate glycosphingolipids. Information on glycolipids of fungi, plants, and invertebrates is covered elsewhere (Chapters 20 and 23–26), as are glycosylphosphatidylinositols (GPIs), glycolipids attached to proteins as membrane anchors (Chapter 12). This chapter describes the characteristic features of GSLs, pathways for their biosynthesis, and insights into their biological roles in membrane structure, host–pathogen interactions, cell–cell recognition, and modulation of membrane protein function.

Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.

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