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Glycans in Acquired Human Diseases.

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Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017.Chapter 46.
2017.

Author information

1
Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
2
Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
3
Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
4
Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
5
Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
6
Professor of Mycology, ETH Zürich, Zürich, Switzerland
7
Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
8
Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
9
Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
10
Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
11
Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
12
Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

Excerpt

Many noninherited human diseases are caused or influenced by acquired changes in glycan synthesis or recognition. This chapter lists a few examples, their proposed mechanisms, and a few therapies. Knowing the altered glycans or changes in glycan-binding proteins, and whether or not they are the primary cause, can improve diagnosis or therapies. Glycosylation changes in cancer and in inherited human genetic disorders are discussed separately in Chapters 47 and 45, respectively.

Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.

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