Format

Send to

Choose Destination

Glycosylphosphatidylinositol Anchors.

Source

Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017.Chapter 12.
2017.

Author information

1
Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
2
Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
3
Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
4
Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
5
Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
6
Professor of Mycology, ETH Zürich, Zürich, Switzerland
7
Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
8
Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
9
Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
10
Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
11
Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
12
Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

Excerpt

Plasma membrane proteins are either peripheral proteins or integral membrane proteins. The latter include proteins that span the lipid bilayer once or several times, and another class that are covalently attached to lipids. Proteins attached to glycosylphosphatidylinositol (GPI) via their carboxyl termini are generally found in the outer leaflet of the lipid bilayer and face the extracellular environment. The GPI membrane anchor may be conveniently thought of as an alternative to the single transmembrane domain of type-1 integral membrane proteins. This chapter reviews the discovery, distribution, structure, biosynthesis, properties, and suggested functions of GPI membrane anchors and related molecules.

Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.

Supplemental Content

Support Center