Format

Send to

Choose Destination
Minim Invasive Ther Allied Technol. 2018 Jun;27(3):186-190. doi: 10.1080/13645706.2017.1365728. Epub 2017 Sep 6.

Anti-Müllerian hormone levels before and after uterine artery embolization.

Author information

1
a Department of Obstetrics and Gynecology , University of California at Los Angeles, David Geffen School of Medicine , Los Angeles , CA , USA.
2
b Med Institute Inc , West Lafayette , IN , USA.
3
c COOK® Research, Inc. , West Lafayette , IN , USA.

Abstract

OBJECTIVE:

To determine the effects of uterine artery embolization (UAE) on ovarian reserve as measured by Anti-Müllerian hormone (AMH) levels.

MATERIAL AND METHODS:

Non-randomized, observational study of 89 women 23-40 years of age who received UAE. Control hormone levels were measured prior to UAE and the first post-embolization measurement was taken at various times post-procedure (mean = 190 ± 229 days).

RESULTS:

Historical work verified by our earlier work has shown that AMH levels decline with age. Regression analysis allows us to determine whether UAE contributes to a greater decline in AMH values over that naturally occurring with aging. The effect of the procedure was found to contribute no deleterious effect to the natural decline in AMH levels. In addition, multiple blood draws were obtained from 32 patients up to 47 months post-UAE. Regression studies with these patients as their own controls showed no long-term diminishment of ovarian reserve due to the UAE procedure.

CONCLUSIONS:

Earlier reported data are consistent with larger sample size. UAE does not affect ovarian reserve in women <40 as evidenced by no significant change in AMH levels after embolization. Women who are of reproductive age and have uterine fibroids can consider UAE without concern for adverse effects on their fertility.

KEYWORDS:

Anti-Müllerian hormone; embolization; fertility; uterine artery embolization

PMID:
28876143
DOI:
10.1080/13645706.2017.1365728
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center