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Protein Cell. 2017 Oct;8(10):772-775. doi: 10.1007/s13238-017-0459-6.

Highly efficient base editing in human tripronuclear zygotes.

Zhou C1,2, Zhang M3, Wei Y1, Sun Y2,4,5,6, Sun Y3, Pan H1,7, Yao N3, Zhong W3, Li Y2,4,5,6, Li W8, Yang H9, Chen ZJ10,11.

Author information

1
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
2
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
3
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
4
Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
5
Institute of Biomedical Sciences, Fudan University, Medical College, Shanghai, 200032, China.
6
Shanghai Center for Bioinformation Technology, Shanghai Industrial Technology Institute, Shanghai, 201203, China.
7
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresource, Guangxi University, Nanning, 530004, China.
8
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. liweiping@renji.com.
9
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. huiyang@ion.ac.cn.
10
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. chenzijiang@hotmail.com.
11
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China. chenzijiang@hotmail.com.
PMID:
28875305
PMCID:
PMC5636752
DOI:
10.1007/s13238-017-0459-6
[Indexed for MEDLINE]
Free PMC Article

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