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FEBS Lett. 1987 Aug 31;221(1):129-33.

Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.

Erratum in

  • FEBS Lett 1988 Jan 18;227(1):85.


Intra-individual tissue-specific restriction fragment length polymorphism (RFLP) has been demonstrated in DNA isolated from different mammalian tissues using cDNAs of alpha- and beta-subunits of Na+,K+-ATPase as hybridization probes. We propose that the RFLPs could result from gene rearrangements in the gene loci for the alpha- and beta-subunits of Na+,K+-ATPase. The changes in restriction patterns have been shown to occur during embryonic development and tumor formation. In addition, the tissue specificity of the expression of different genes of the family of Na+,K+-ATPase genes and their low expression in tumor cells have been demonstrated.

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