Format

Send to

Choose Destination
Blood. 2017 Oct 12;130(15):1693-1698. doi: 10.1182/blood-2017-06-780882. Epub 2017 Sep 5.

Inflammation: a key regulator of hematopoietic stem cell fate in health and disease.

Author information

1
Division of Hematology, Department of Medicine, and Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.

Abstract

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as a whole. Here we detail recent advances and unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging, and hematological malignancy.

PMID:
28874349
PMCID:
PMC5639485
DOI:
10.1182/blood-2017-06-780882
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center