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Int J Mol Sci. 2017 Sep 5;18(9). pii: E1906. doi: 10.3390/ijms18091906.

Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future.

Author information

1
Seafood Research Center, IACF, Silla University, Advanced Seafood Processing Complex #606, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea. imranagrarian3@gmail.com.
2
Seafood Research Center, IACF, Silla University, Advanced Seafood Processing Complex #606, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea. jsc1008@silla.ac.kr.
3
Major in Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University, 140, Baegyang-daero 700 beon-gil, Sasang-gu, Busan 46958, Korea. jsc1008@silla.ac.kr.

Abstract

β-Glucans are a group of biologically-active fibers or polysaccharides from natural sources with proven medical significance. β-Glucans are known to have antitumor, anti-inflammatory, anti-obesity, anti-allergic, anti-osteoporotic, and immunomodulating activities. β-Glucans are natural bioactive compounds and can be taken orally, as a food supplement, or as part of a daily diet, and are considered safe to use. The medical significance and efficiency of β-glucans are confirmed in vitro, as well as using animal- and human-based clinical studies. However, systematic study on the clinical and physiological significance of β-glucans is scarce. In this review, we not only discuss the clinical and physiological importance of β-glucans, we also compare their biological activities through the existing in vitro and animal-based in vivo studies. This review provides extensive data on the clinical study of β-glucans.

KEYWORDS:

anti-obesity; anti-osteoporosis; antitumor; bioactive polysaccharides; immunomodulation; β-glucans

PMID:
28872611
PMCID:
PMC5618555
DOI:
10.3390/ijms18091906
[Indexed for MEDLINE]
Free PMC Article

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