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Clin Exp Hypertens. 2018;40(3):244-250. doi: 10.1080/10641963.2017.1356845. Epub 2017 Sep 5.

Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults.

Author information

1
a Graduate School of Comprehensive Human Sciences , University of Tsukuba , Ibaraki , Japan.
2
b Division of Nephrology and Hypertension, Department of Internal Medicine , St. Marianna University School of Medicine , Kanagawa , Japan.
3
c Department of Anatomy , St. Marianna University School of Medicine , Kanagawa , Japan.
4
d CMIC Company Limited , Tokyo , Japan.
5
e Faculty of Health and Sport Sciences , University of Tsukuba , Ibaraki , Japan.
6
f Research Team for Promoting Independence of the Elderly , Tokyo Metropolitan Institute of Gerontology , Tokyo , Japan.
7
g JCHO Tokyo Takanawa Hospital , Tokyo , Japan.

Abstract

BACKGROUND:

To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults.

METHODS:

This was a cross-sectional study of 249 middle- and older-aged adults (aged 46-83 years). We measured urinary L-FABP levels and central hemodynamic parameters, including SEVR, calculated by pulse wave analysis using an applanation tonometry.

RESULTS:

In the participants stratified in accordance with the tertiles of urinary L-FABP levels, SEVR decreased in a stepwise fashion with increasing tertiles (p < 0.001). Furthermore, this association remains significant after the consideration of various confounders. On the contrary, urinary albumin levels were not independently related with SEVR.

CONCLUSION:

Our results demonstrated that urinary L-FABP levels were independently associated with the SEVR of the middle- and older-aged adults. This result suggests that the increase in urinary L-FABP levels even within the normal range might be related to the decrease in myocardial perfusion (SEVR).

KEYWORDS:

Cardiovascular disease; intra-renal microcirculation; myocardial perfusion; pulse wave analysis; tubular biomarker

PMID:
28872349
DOI:
10.1080/10641963.2017.1356845
[Indexed for MEDLINE]

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