Format

Send to

Choose Destination
Adv Ther. 2017 Oct;34(10):2181-2198. doi: 10.1007/s12325-017-0605-9. Epub 2017 Sep 4.

The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer.

Author information

1
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain. flopez_1981@yahoo.es.
2
Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, Oviedo, Spain. flopez_1981@yahoo.es.
3
Professorial Unit, Ear Institute, University College London, London, UK.
4
Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, Oviedo, Spain.
5
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
6
Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
7
Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, ILL, USA.
8
Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
9
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
10
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
11
University of Udine School of Medicine, Udine, Italy.
12
Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Abstract

The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.

KEYWORDS:

Endoscopic surgery; Histology; Oncology; Paranasal cavities; Radiotherapy; Sinonasal cancer

PMID:
28871554
DOI:
10.1007/s12325-017-0605-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center